adaptive immune responses – Communicable Diseases Research

Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination

Article

Published on 2022-09-022022-11-16
Journal: Frontiers in Immunology
[Category] SARS, 변종,

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

COVID-19의 적응 면역 구획 전반에 걸친 항원 수용체 레퍼토리 파괴의 글로벌 패턴

Article

Published on 2022-08-232022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] SARS, 변종, 치료기술,

Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution

급성 질환 해결 후 1~8개월 후 코로나19 환자의 장내 세균총 이상 감지

Article

Published on 2022-08-172022-09-11
Journal: International Journal of Environmental Research an
[Category] 치료제,

[키워드] acute COVID-19 acute disease acute phase adaptive immune responses addition alopecia anti-SARS-CoV-2 antibody Antibiotic therapy Antibiotics Anxiety bidirectional Bifidobacterium C-reactive protein Clinical data clinical manifestations controls COVID-19 severity Cytokine storm Depression Desulfovibrio detection disease DNA Dysbiosis Dyspnea evaluate fatigue Hypothesis immune response immune responses Immune status Interaction intestinal intestinal microbiota memory memory loss microbes microbiota modulating modulation Month myalgia pandemic Patient post-COVID-19 Post-COVID-19 patients Prevotella quantified reported symptoms Resolution Sequelae. sequenced severity significant difference significant differences Stool stool samples target the patient Therapeutic approach These data use of antibiotics viral infections with COVID-19
[DOI] 10.3390/ijerph191610189 PMC 바로가기 [Article Type] Article

Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

Article

Published on 2022-08-112022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 치료제,

[키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA microRNA. Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19
[DOI] 10.3389/fimmu.2022.968991 PMC 바로가기

Defying convention in the time of COVID-19: Insights into the role of γδ T cells

Article

Published on 2022-08-112022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 치료제,

Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals

단핵구 골수 유래 억제 세포는 회복된 SARS CoV2에 감염된 개인의 T 세포 반응을 억제합니다

Article

Published on 2022-06-242022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제,

[키워드] adaptive immune responses Antigen arginase caused CD11b CD14 CD33 CD57 Cell characterized clinical recovery coronavirus disease Coronavirus disease 2019 correlated COVID-19 CX3CR1 CXCL1 CXCL2 cytokine production Cytokine storm Cytokines depleting dominant downregulated DQA1 DQB1 effector memory expansion Frequency function functional functions Gene Expression HLA-B HLA-DQA1 HLA-DQB1 HLA-DR Hyperinflammatory Hyperinflammatory response IL-6 IL1β immune immune activation immune responses individual individuals infected individual Infection membrane monocytic-myeloid derived suppressor cells mononuclear cell NLRP3 nucleocapsid pathway Pathway analysis Pathways PBMC PD1 peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells plasma quantity recall recovered regulate remained response RNA-Seq ROS SARS Coronavirus SARS coronavirus 2 SARS CoV2 infection shown spike glycoprotein subset suppress suppresse suppressed suppressor T cell T cell response T cell responses T-cell T-cell responses target TGFβ transcriptional transcriptomic transcriptomic (RNA-Seq). Vaccine viral infection virus
[DOI] 10.3389/fimmu.2022.894543 PMC 바로가기 [Article Type] Article

Enhanced host immune responses in presence of HCV facilitate HBV clearance in coinfection

Article

Published on 2022-06-012023-06-13
Journal: Virologica Sinica
[Category] B형 간염, Fulltext,

[키워드] adaptive immune responses Coinfection Hepatitis B virus (HBV) hepatitis C virus (HCV) Immunocompetent mouse model viral-host interaction.
[DOI] 10.1016/j.virs.2022.04.001 PMC 바로가기

Adaptive Immune Responses and Immunity to SARS-CoV-2

SARS-CoV-2에 대한 적응 면역 반응 및 면역

Review

Published on 2022-05-042022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종,

[키워드] activated Activation adaptive Adaptive immune response adaptive immune responses Adaptive immunity Antigen antigen-presenting cell antigen-presenting cells B cell B cell receptors B.1.1.529 B.1.617.2 backbone biological interaction Blood Blood donors Breakthrough infection breakthrough infections cellular Cellular immune response cellular immunity cellular response Clonality competence COVID-19 COVID-19 pandemic defend Defense defense mechanism Delta demonstrated heparinized blood Host humoral Humoral response humoral responses IgA immune immune reaction immune responses Immunity Immunocompromised Immunocompromised patient Immunocompromised patients Immunological memory immunology induce Infection interferon gamma interferon gamma. Interferon-gamma knowledge long-lasting maturation mechanism memory mucosal nasal omicron pandemic peptides Research response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 T cell memory shown stimulated T cell T cell memory T cells the SARS-CoV-2 translate undetectable Vaccine Vaccines variants variants of concern Viral antigen viral particle virus
[DOI] 10.3389/fimmu.2022.848582 PMC 바로가기 [Article Type] Review

Differences in SARS-CoV-2 Vaccine Response Dynamics Between Class-I- and Class-II-Specific T-Cell Receptors in Inflammatory Bowel Disease

염증성 장 질환에서 클래스 I 및 클래스 II 특정 T 세포 수용체 간의 SARS-CoV-2 백신 반응 역학의 차이

Article

Published on 2022-04-082022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

[키워드] Ad26 Ad26.COV2.S Adaptive immune response adaptive immune responses age analyzed antibody antibody levels Antigen antigens BNT162b2 booster bowel characterized clone clones Cohort conditions Critical deficiencies deficiency difference Dynamics expansion Factor HCWs Health care Health care worker health care workers IBD immune factors immune response immune responses Immune-mediated immunodeficiency immunomodulatory induce Infection Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases intestinal mechanism molecular mRNA mRNA vaccine mRNA vaccine. mRNA-1273 vaccine Patient patients protocols response responses robust SARS-CoV-2 SARS-CoV-2 (COVID-19) SARS-CoV-2 vaccination sequenced Sequencing significant difference significant differences Spectrum stratified subset T-cell T-cell receptor T-cell repertoire T-cell Response T-cell responses T-cells TCR the patient Treatment understanding vaccination vaccination response vaccination schedule Vaccine
[DOI] 10.3389/fimmu.2022.880190 PMC 바로가기 [Article Type] Article

Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses

Reviews

Published on 2022-02-242022-10-05
Journal: Nature Immunology
[Category] COVID19(2023년), SARS, 비임상,